5-MTHF XS NG
Extra-Strength Quatrefolic® (6S)-5-Methyltetrahydrofolate for Optimal Methylation, Nervous System Health, Mood Balance, and Cellular Vitality
Folate is critical for methylation—a process that supports DNA repair, neurotransmitter production, detoxification, homocysteine metabolism, and red blood cell formation. Many individuals have MTHFR gene variations that impair conversion of folic acid to its active form, (6S)-5-MTHF, leading to suboptimal folate status even with adequate intake. 5-MTHF XS NG delivers Quatrefolic®—the patented, glucosamine-stabilized (6S)-5-methyltetrahydrofolate—in an extra-strength 1,360 mcg DFE dose per capsule. This directly active, bioavailable form raises plasma folate more efficiently than folic acid or other 5-MTHF salts, bypassing conversion steps and avoiding unmetabolized folic acid buildup.
In a clean vegetarian capsule, this high-potency formula supports healthy methylation, nervous system function, mood stability, cognitive clarity, and overall cellular health—ideal for those with methylation challenges, prenatal needs, mood/energy concerns, or seeking advanced folate support.*
Key Benefits
Supports Optimal Methylation and Homocysteine Balance Quatrefolic® 5-MTHF directly participates in the methylation cycle, helping convert homocysteine to methionine and supporting SAMe production for neurotransmitter, DNA, and detoxification pathways.*
Promotes Nervous System and Cognitive Health Active folate crosses the blood-brain barrier to support neurotransmitter synthesis (serotonin, dopamine), myelin maintenance, and neural function—contributing to mental clarity, focus, and mood balance.*
Supports Healthy Red Blood Cell Formation Folate is essential for DNA synthesis and red blood cell maturation—helping maintain normal hemoglobin levels, oxygen transport, and energy without synthetic folic acid accumulation.*
Provides Superior Bioavailability Over Folic Acid Quatrefolic® raises plasma folate more effectively and avoids potential UMFA (unmetabolized folic acid) issues—ensuring reliable support even in those with MTHFR variations.*
Why Quatrefolic® in Extra-Strength Form?
Quatrefolic® is a patented, glucosamine-stabilized (6S)-5-MTHF with exceptional stability, solubility, and bioavailability compared to calcium salt forms or folic acid. The XS (extra-strength) 1,360 mcg DFE dose delivers meaningful support in one capsule—perfect for targeted methylation needs, prenatal planning, or advanced folate supplementation in a clean, allergen-free vegetarian capsule.*
Supplement Facts
Serving Size: 1 Capsule Servings Per Container: 60
| Amount Per Serving | % Daily Value | |
|---|---|---|
| Folate (from 1,000 mcg as Quatrefolic® (6S)-5-methyltetrahydrofolic acid, glucosamine salt) | 1,700 mcg DFE | 425% |
** Daily Value not established.
Other Ingredients Microcrystalline cellulose, HPMC (capsule), ascorbyl palmitate, and silica.
Does Not Contain Gluten, dairy, soy, artificial colors, sweeteners, or preservatives. Vegetarian formula. Made in a GMP-compliant facility.
Suggested Use Take one capsule daily with a meal, or as directed by your healthcare professional.
Cautions Consult your healthcare professional prior to use. Individuals taking medication (especially methotrexate or anticonvulsants) should discuss potential interactions with their healthcare professional. If you are pregnant or nursing, consult your physician before taking this product. Keep out of reach of children. Do not use if tamper seal is damaged.
Activate methylation with the most bioavailable folate. 5-MTHF XS – because Quatrefolic® delivers superior support for mood, energy, cognition, and cellular health in one potent capsule.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.